Anita Harding










































Anita Harding
Born
Anita Elizabeth Harding


(1952-09-17)17 September 1952
Died 11 September 1995(1995-09-11) (aged 42)
Residence
Birmingham, UK
Nationality
Irish-British
Education King Edward VI High School
Alma mater UCL Medical School
Occupation Neurologist
Known for The first identification of a mitochondrial DNA mutation in human disease, and the concept of tissue heteroplasmy of mutant mitochondrial DNA
Spouse(s)

P.K. Thomas (m. 1977–1995)

Anita Elizabeth Harding (17 September 1952 – 11 September 1995) was an Irish-British neurologist, and Professor of Clinical Neurology at the Institute of Neurology of the University of London.[1] She is known for the discovery with Ian Holt and John Morgan-Hughes of the "first identification of a mitochondrial DNA mutation in human disease and the concept of tissue heteroplasmy of mutant mitochondrial DNA", published in Nature in 1986.[2]




Contents






  • 1 Biography


  • 2 Work


  • 3 References


  • 4 External links





Biography


Born in Ireland, Harding was educated at the King Edward VI High School for Girls and the Royal Free Hospital Medical School, where she qualified in 1975.[3] She married neurology professor P.K. Thomas two years later, and trained as a neurologist.[1]


She died of colorectal cancer, 6 days before her 43rd birthday and shortly before she was to take up the Chair in Clinical Neurology at the Institute of Neurology in Queen Square, London. On learning of her terminal condition, she is reported to have said "[A]t least I won't have to buy Windows 95".[1]


In 1995, she was posthumously awarded the Association of British Neurologists Medal for her contributions to the science of neurology.



Work


Harding made several significant contributions in the field of inherited neurologic disorders. Her major achievements were:



  • Classification of the peripheral neuropathies and hereditary ataxias, the first identification of a mitochondrial DNA mutation in human disease (in Kearns-Sayre syndrome)

  • Identification of trinucleotide repeats in degenerative neurologic diseases (e.g. Huntington's disease).


She also worked extensively on the population genetics of disorders with ethnic distribution.[1][3] She has published over 200 articles, and edited 3 books.[2]



References





  1. ^ abcd Poulton J, Huson SM (1996). "Anita Harding (1952-95): In Memoriam". Am J Hum Genet. 58 (1): 235–236. PMC 1914930..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output .citation q{quotes:"""""""'""'"}.mw-parser-output .citation .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-maint{display:none;color:#33aa33;margin-left:0.3em}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}


  2. ^ ab Compston, Alastair (2009). "Anita Harding (1952-1995)" (PDF). ACNR. 9 (4): 28.


  3. ^ ab Dubowitz V (1995). "Anita Harding (1952–1995)". Neuromusc Dis. 5 (6): 519–520. doi:10.1016/0960-8966(95)90017-9.




External links






  • Anita Harding (1952-1995)








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