選擇性剪接







选择性剪接产生两个蛋白异型体


選擇性剪接（英语：Alternative splicing；又称“可变剪接”）是基因表达的方式，在複雜的動物例如人類细胞是非常普遍的。真核细胞的基因序列中，包含了內含子（intron）與外顯子（exon），兩者交互穿插。其中內含子在基因轉錄成mRNA前体後會被RNA剪接體移除，剩下的外顯子才是能夠存在於成熟mRNA（之後再進一步轉譯成蛋白質）的片段。


而選擇性剪接便是利用這樣的特性，一條未經剪接的RNA，含有的多種外顯子被剪成的不同組合，可轉譯出不同的蛋白質。就能將同一基因中的外顯子以不同的組合方式來表現，使一個基因在不同時間、不同環境中能夠製造出不同的蛋白質（基因表达调控），可增加生理狀況下系統的複雜性或適應性。例如抗體的製造。


















  • 查

  • 论

  • 编


转录后修饰

细胞核

前信使RNA · 5'端加帽 · 多腺苷酸化 · 多聚腺苷酸结合蛋白（CPSF、CstF、PAP、

PAB2、CFI及CFII）


RNA剪接：
內含子 / 外顯子 · snRNA · snRNP · 剪接體（次要剪切体（英语：Minor spliceosome）、U1（英语：U1 spliceosomal RNA）） · 選擇性剪接 · 前体mRNA加工因子 （PLRG1、PRPF3、PRPF4、PRPF4B、PRPF6、PRPF8、PRPF18、PRPF19、PRPF31、PRPF38A、PRPF38B、PRPF39、PRPF40A及PRPF40B）


RNA编辑 · 多聚尿苷酸化
细胞质


  • 5'端帽甲基化


  • mRNA去帽（英语：Messenger RNA decapping）

    • DCP1A

    • DCP1B

    • DCP2

    • DCPS

    • EDC3

    • EDC4
















  • 查

  • 论

  • 编


遗传学索引

描述


  • 生化


  • 基因表达

    • DNA（复制

    • 周期蛋白

    • 遗传重组

    • 修复




  • 转录

    • 转录因子与细胞内受体

    • 辅调节因子

    • RNA

    • 重复序列

    • 转录后修饰




  • 翻译

    • 核糖体亚基

    • 翻译后修饰

    • 分拣蛋白




  • DNA/RNA结合蛋白

    • 核糖核蛋白)


  • 蛋白质

    • 结构域

    • 结构

      • 1°

      • 2°

      • 2+°

      • 3°

      • 4°
疾病


  • Replication and repair（英语：Template:DNA replication and repair-deficiency disorder）

  • Transcription factor（英语：Template:Transcription factor and coregulator deficiencies）

  • Transcription（英语：Template:Disorders of transcription and post transcriptional modification）

  • Translation（英语：Template:Disorders of translation and posttranslational modification）





Comments

Post a Comment

Popular posts from this blog

Information security

Image
This article is part of a series on Information security Related security categories Internet security Cyberwarfare Computer security Mobile security Network security Threats Computer crime Vulnerability Eavesdropping Malware Spyware Ransomware Trojans Viruses Worms Rootkits Bootkits Keyloggers Screen scrapers Exploits Backdoors Logic bombs Payloads Denial of service Defenses Computer access control Application security Antivirus software Secure coding Secure by default Secure by design Secure operating systems Authentication Multi-factor authentication Authorization Data-centric security Encryption Firewall Intrusion detection system Mobile secure gateway Runtime application self-protection (RASP) v t e Information security , sometimes shortened to InfoSec , is the practice of preventing unauthorized access, use, disclosure, disruption, modification, inspection, recording or destruction of information. Th...
Read more

Volkswagen Group MQB platform

Image
The Volkswagen Group MQB platform is the company's strategy for shared modular design construction of its transverse, front-engine, front-wheel-drive layout (optional front-engine, four-wheel-drive layout) automobiles. Volkswagen spent roughly $60bn [1] developing this new platform and the cars employing it. The platform underpins a wide range of cars from the supermini class to the mid size SUV class. MQB allows Volkswagen to assemble any of its cars based on this platform across all of its MQB ready factories. This allows the Volkswagen group flexibility to shift production as needed between its different factories. Beginning in 2012, Volkswagen Group marketed the strategy under the code name MQB , which stands for Modularer Querbaukasten , translating from German to "Modular Transversal Toolkit" or "Modular Transverse Matrix". [2] [3] MQB is one strategy within VW's overall MB (Modularer Baukasten or modular matrix) program which also includes th...
Read more

Daniel Guggenheim

Image
Daniel Guggenheim 1925 photo Born ( 1856-07-09 ) July 9, 1856 Philadelphia, Pennsylvania Died September 28, 1930 (1930-09-28) (aged 74) Port Washington, New York Alma mater Peirce College Known for Battle for control of ASARCO Daniel Guggenheim Medal Spouse(s) Florence Shloss Children Meyer Robert Guggenheim Harry Guggenheim Gladys Eleanor Guggenheim Parent(s) Meyer Guggenheim Barbara Guggenheim Daniel Guggenheim, 1910 Daniel Guggenheim (July 9, 1856 – September 28, 1930) was an American mining magnate and philanthropist, and a son of Meyer and Barbara Guggenheim. Contents 1 Biography 2 Personal life 2.1 Aviation 2.2 Alaska 3 See also 4 References 5 Further reading 6 External links Biography Born and raised in Philadelphia, Daniel Guggenheim was sent to Switzerland as a young man to study the Swiss lace and embroidery business, and to serve as a buyer for his father's import firm. The...
Read more