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Hepatosplenomegaly
Specialty
Gastroenterology
Hepatosplenomegaly (commonly abbreviated HSM) is the simultaneous enlargement of both the liver (hepatomegaly) and the spleen (splenomegaly). Hepatosplenomegaly can occur as the result of acute viral hepatitis, infectious mononucleosis, and histoplasmosis or it can be the sign of a serious and life-threatening lysosomal storage disease. Systemic venous hypertension can also increase the risk for developing hepatosplenomegaly, which may be seen in those patients with right-sided heart failure.
Contents
1Common causes
2Rare disorders
3References
4External links
Common causes
Infection:
Acute viral hepatitis[1][2]
Infectious mononucleosis[1][2]
Cytomegalovirus[1][2]
Rubella[1]
Brucella infection[3]
Hyper active malaria syndrome[1]
Leishmaniasis[1]
Fasciolosis
Typhoid fever[4]
Schistosomiasis or filariasis importants
Septicemic plague
Histoplasmosis
Hematologic diseases:
Myeloproliferative disease[1][2]
Leukaemia[1][2]
Lymphoma[1][2]
Pernicious anaemia[2]
Sickle cell anaemia[2]
Thalassaemia[2]
Myelofibrosis[1]
Metabolic disease:
Niemann-Pick disease[citation needed]
Gaucher's disease[citation needed]
Hurler's syndrome[citation needed]
Chronic liver disease and portal hypertension:
Chronic active hepatitis[2]
Amyloidosis[2]
Acromegaly[2]
Systemic lupus erythematosus[2]
Sarcoidosis
Human African trypanosomiasis[citation needed]
Drug abuse[citation needed]
Obesity[citation needed]
Rare disorders
Lipoproteinlipase deficiency
Multiple sulfatase deficiency
Osteopetrosis
Adult-onset Still's disease (AOSD)
References
^ abcdefghijmedcyclopaedia: Hepatosplenomegaly Retrieved on Nov 23, 2009
^ abcdefghijklmGPNotebook: hepatosplenomegaly Retrieved on Nov 23, 2009
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