Dyserythropoiesis








Dyserythropoiesis
Iron-deficiency Anemia, Peripheral Blood Smear (4422704616).jpg
A peripheral blood smear of a patient with iron-deficiency anemia, an example of an acquired dyserythropoiesis

Dyserythropoiesis refers to the defective development of red blood cells, also called erythrocytes.[1] This problem can be congenital, acquired, or inherited.[2] Some red blood cells may be destroyed within the bone marrow during the maturation process, whereas others can enter the circulation with abnormalities.[3] These abnormalities can be functional and/or morphological, which can lead to anemia since there may be increased turnover of red blood cells.[1][2] There are a number of diseases that cause dyserythropoiesis. Congenital/inherited causes include congenital dyserythropoietic anemia, thalassemia, pyruvate kinase deficiency, hereditary pyropoikilocytosis, and abetalipoproteinemia. [2] Acquired causes include nutrient deficiency/malnutrition (e.g. cobalamine, folate, and iron), myelodysplasia, HIV infection, and certain medications (e.g. zidovudine). [2]



See also



  • Erythropoiesis

  • Erythrocyte

  • Congenital dyserythropoietic anemia



References





  1. ^ ab Orkin, S.H.; Nathan, D.G. (2009). Nathan and Oski's Hematology of Infancy and Childhood. ClinicalKey 2012. Saunders/Elsevier. p. 360. ISBN 978-1-4160-3430-8. Retrieved 2017-10-31..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}


  2. ^ abcd Shinton, N.K. (2007). Desk Reference for Hematology, Second Edition. CRC Press. p. 267. ISBN 978-1-4200-0512-7. Retrieved 2017-10-31.


  3. ^ Hoffbrand, A.V.; Catovsky, D.; Tuddenham, E.G.D. (2008). Postgraduate Haematology (in German). Wiley. p. 202. ISBN 978-1-4051-4353-0. Retrieved 2017-10-31.









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