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; ; Route 52
Route information
	Maintained by MoDOT;
Length	173 mi (278 km)
Existed	1926–present
Major junctions
West end	; K-52 at the Kansas state line
East end	; Route 133 east of St. Elizabeth;
Highway system

Route 52 is an east/west highway running from its eastern terminus at Route 133 7 miles (11 km) east of St. Elizabeth to the Kansas state line where it continues as K-52 (this road continues for 23 additional miles). Highway 52 comprises 173 miles (278 km) of primarily two-lane roadway in Missouri.

Missouri Route 52 eastbound shortly after ending a concurrency with I-49/US 71.

Route 52 was formerly Route 24 between Eldon and the Kansas state line. The numbering change was to avoid duplication with the new U.S. Route 24 which came through Missouri in 1926.

Major intersections

County	Location	Destinations	Notes
Bates		K-52 west to US-69	Kansas state line
		I-49 / US 71 – Kansas City, Joplin	I-49 exit 131
	Butler	BL I-49 north (South Orange Street)	west end of I-49 Bus. overlap
		I-49 north / US 71 north – Kansas City	westbound exit and eastbound entrance; east end of I-49 Bus. overlap; west end of I-49 / US 71 overlap; Route 52 west follows exit 130
		I-49 south / US 71 south – Joplin	east end of I-49 / US 71 overlap; Route 52 east follows exit 129
Henry	Deepwater	Route 52 Bus. east – Deepwater
		Route 13 south – Springfield	interchange; west end of Route 13 overlap
		Route 52 Bus. west – Deepwater
	Clinton	Route 13 Bus. north – Clinton
		Route 7 south / Route 18 west – Clinton, Warsaw, Historic Downtown Clinton	west end of Route 7 overlap
		Route 7 north / Route 13 north – Warrensburg, Clinton	interchange; east end of Route 7 / Route 13 overlap
	Windsor	Route 2 west (Benton Street)
Pettis		Route 127 north – Green Ridge
Benton–Pettis county line	Windsor Junction	US 65 north – Sedalia	west end of US 65 overlap
Benton	Cole Camp Junction	US 65 south – Warsaw	interchange; east end of US 65 overlap
Morgan		Route 135 north – Florence	west end of Route 135 overlap
	Stover	Route 135 south to Route 5 – Business District	east end of Route 135 overlap
	Versailles	Route 5 south / Route W south – Gravois Mills	west end of Route 5 overlap
		Route 5 north – Tipton	east end of Route 5 overlap
Miller	Eldon	US 54 Bus. east	west end of US 54 Bus. overlap
		US 54 – Jefferson City, Lake of the Ozarks	interchange; east end of US 54 Bus. overlap
	Tuscumbia	Route 17 north – Eugene	west end of Route 17 overlap
		Route 17 south – Iberia, Fort Leonard Wood	east end of Route 17 overlap
		Route 133 – Meta, Crocker
1.000 mi = 1.609 km; 1.000 km = 0.621 mi Concurrency terminus