POLD3

POLD3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1U76, 3E0J, 2N1G
Identifiers
Aliases	POLD3, P66, P68, PPP1R128, polymerase (DNA) delta 3, accessory subunit, DNA polymerase delta 3, accessory subunit
External IDs	MGI: 1915217 HomoloGene: 38202 GeneCards: POLD3
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 74,493,851 bp[1] End 74,669,117 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 100,082,111 bp[2] End 100,121,565 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding • DNA-directed DNA polymerase activity Cellular component • delta DNA polymerase complex • cell nucleus • nucleoplasm • cytoplasm Biological process • nucleotide-excision repair, DNA gap filling • DNA synthesis involved in DNA repair • DNA replication • translesion synthesis • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA incision • telomere maintenance • DNA damage response, detection of DNA damage • DNA-dependent DNA replication • nucleotide-excision repair, DNA incision, 5'-to lesion • DNA repair • cellular response to DNA damage stimulus • telomere maintenance via semi-conservative replication • mismatch repair Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10714	67967
Ensembl	ENSG00000077514	ENSMUSG00000030726
UniProt	Q15054	Q9EQ28
RefSeq (mRNA)	NM_006591 NM_001363597	NM_133692
RefSeq (protein)	NP_006582 NP_001350526	NP_598453
Location (UCSC)	Chr 11: 74.49 – 74.67 Mb	Chr 7: 100.08 – 100.12 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

DNA polymerase delta subunit 3 is an enzyme that in humans is encoded by the POLD3 gene.^[5][6] It is a component of the DNA polymerase delta complex.

Interactions

POLD3 has been shown to interact with PCNA.^[7][8]

References

1. 
   ^ ^abc GRCh38: Ensembl release 89: ENSG00000077514 - Ensembl, May 2017
   


2. 
   ^ ^abc GRCm38: Ensembl release 89: ENSMUSG00000030726 - Ensembl, May 2017
   


3. 
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4. 
   ^ "Mouse PubMed Reference:".
   


5. 
   ^ Hughes P, Tratner I, Ducoux M, Piard K, Baldacci G (Jun 1999). "Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts". Nucleic Acids Res. 27 (10): 2108–14. doi:10.1093/nar/27.10.2108. PMC 148430. PMID 10219083.
   


6. 
   ^ "Entrez Gene: POLD3 polymerase (DNA-directed), delta 3, accessory subunit".
   


7. 
   ^ Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P (Dec 2001). "Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta". J. Biol. Chem. 276 (52): 49258–66. doi:10.1074/jbc.M106990200. PMID 11595739.
   


8. 
   ^ Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
   

Further reading

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• 
  Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
  


• 
  Zeng XR, Jiang Y, Zhang SJ, Hao H, Lee MY (1994). "DNA polymerase delta is involved in the cellular response to UV damage in human cells". J. Biol. Chem. 269 (19): 13748–51. PMID 7910606.
  


• 
  Longley MJ, Pierce AJ, Modrich P (1997). "DNA polymerase delta is required for human mismatch repair in vitro". J. Biol. Chem. 272 (16): 10917–21. doi:10.1074/jbc.272.16.10917. PMID 9099749.
  


• 
  Mo J, Liu L, Leon A, Mazloum N, Lee MY (2000). "Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA". Biochemistry. 39 (24): 7245–54. doi:10.1021/bi0000871. PMID 10852724.
  


• 
  Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P (2002). "Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta". J. Biol. Chem. 276 (52): 49258–66. doi:10.1074/jbc.M106990200. PMID 11595739.
  


• 
  Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
  


• 
  Pohler JR, Otterlei M, Warbrick E (2006). "An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit". BMC Mol. Biol. 6: 17. doi:10.1186/1471-2199-6-17. PMC 1187890. PMID 16000169.
  


• 
  Takemura M, Yoshida S, Akiyama T, Kitagawa M, Yamada Y (2006). "Role of the second-largest subunit of DNA polymerase alpha in the interaction between the catalytic subunit and hyperphosphorylated retinoblastoma protein in late S phase". Biochim. Biophys. Acta. 1764 (9): 1447–53. doi:10.1016/j.bbapap.2006.06.015. PMID 16935576.
  


• 
  Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  


• 
  Masuda Y, Suzuki M, Piao J, Gu Y, Tsurimoto T, Kamiya K (2007). "Dynamics of human replication factors in the elongation phase of DNA replication". Nucleic Acids Res. 35 (20): 6904–16. doi:10.1093/nar/gkm822. PMC 2175312. PMID 17932049.
  

v t e DNA replication (comparing Prokaryotic to Eukaryotic)
Initiation	Prokaryotic (initiation) Pre-replication complex dnaC Cdc6 Helicase dnaA dnaB T7 Primase dnaG Eukaryotic (preparation in G1 phase) Pre-replication complex Origin recognition complex ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 Cdc6 Cdt1 Minichromosome maintenance MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 Licensing factor Autonomously replicating sequence Single-strand binding protein SSBP2 SSBP3 SSBP4 RNase H RNASEH1 RNASEH2A Helicase: HFM1 Primase: PRIM1 PRIM2 Both Origin of replication/Ori/Replicon Replication fork Lagging and leading strands Okazaki fragments Primer
Replication	Prokaryotic (elongation) DNA polymerase III holoenzyme dnaC dnaE dnaH dnaN dnaQ dnaT dnaX holA holB holC holD holE Replisome DNA ligase DNA clamp Topoisomerase DNA gyrase Prokaryotic DNA polymerase: DNA polymerase I Klenow fragment Eukaryotic (synthesis in S phase) Replication factor C RFC1 Flap endonuclease FEN1 Topoisomerase Replication protein A RPA1 Eukaryotic DNA polymerase: alpha POLA1 POLA2 PRIM1 PRIM2 delta POLD1 POLD2 POLD3 POLD4 epsilon POLE POLE2 POLE3 POLE4 DNA clamp PCNA Control of chromosome duplication Both Movement: Processivity DNA ligase
Termination	Telomere: Telomerase TERT TERC DKC1

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