POLD2

POLD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3E0J
Identifiers
Aliases	POLD2, DNA polymerase delta 2, accessory subunit
External IDs	MGI: 1097163 HomoloGene: 4538 GeneCards: POLD2
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p13 Start 44,114,681 bp[1] End 44,124,358 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 5,872,180 bp[2] End 5,878,292 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • protein binding • DNA-directed DNA polymerase activity Cellular component • nucleoplasm • cell nucleus • delta DNA polymerase complex Biological process • nucleotide-excision repair, DNA gap filling • DNA replication • translesion synthesis • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA incision • telomere maintenance • DNA damage response, detection of DNA damage • nucleotide-excision repair, DNA incision, 5'-to lesion • DNA repair • DNA strand elongation involved in DNA replication • cellular response to DNA damage stimulus • telomere maintenance via semi-conservative replication • DNA biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5425	18972
Ensembl	ENSG00000106628	ENSMUSG00000020471
UniProt	P49005	O35654
RefSeq (mRNA)	NM_001127218 NM_001256879 NM_006230	NM_008894 NM_001361942
RefSeq (protein)	NP_001120690 NP_001243808 NP_006221	NP_032920 NP_001348871
Location (UCSC)	Chr 7: 44.11 – 44.12 Mb	Chr 11: 5.87 – 5.88 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene.^[5][6] It is a component of the DNA polymerase delta complex.

Interactions

POLD2 has been shown to interact with PCNA.^[7]

References

1. 
   ^ ^abc GRCh38: Ensembl release 89: ENSG00000106628 - Ensembl, May 2017
   


2. 
   ^ ^abc GRCm38: Ensembl release 89: ENSMUSG00000020471 - Ensembl, May 2017
   


3. 
   ^ "Human PubMed Reference:"..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}
   


4. 
   ^ "Mouse PubMed Reference:".
   


5. 
   ^ Zhang J, Tan CK, McMullen B, Downey KM, So AG (Feb 1996). "Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2)". Genomics. 29 (1): 179–86. doi:10.1006/geno.1995.1229. PMID 8530069.
   


6. 
   ^ "Entrez Gene: POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50kDa".
   


7. 
   ^ Lu, Xiaoqing; Tan Cheng-Keat; Zhou Jin-Qiu; You Min; Carastro L Michael; Downey Kathleen M; So Antero G (Jul 2002). "Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta". J. Biol. Chem. United States. 277 (27): 24340–5. doi:10.1074/jbc.M200065200. ISSN 0021-9258. PMID 11986310.
   

Further reading

.mw-parser-output .refbegin{font-size:90%;margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{list-style-type:none;margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>dd{margin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none}.mw-parser-output .refbegin-100{font-size:100%}

• 
  Hindges R, Hübscher U (1997). "Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2)". Genomics. 44 (1): 45–51. doi:10.1006/geno.1997.4838. PMID 9286699.
  


• 
  Hisama FM, Chen YH, Meyn MS, et al. (2000). "WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts". Cancer Res. 60 (9): 2372–6. PMID 10811112.
  


• 
  Mo J, Liu L, Leon A, et al. (2000). "Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA". Biochemistry. 39 (24): 7245–54. doi:10.1021/bi0000871. PMID 10852724.
  


• 
  Perez A, Leon A, Lee MY (2000). "Characterization of the 5'-flanking region of the gene encoding the 50 kDa subunit of human DNA polymerase delta". Biochim. Biophys. Acta. 1493 (1–2): 231–6. doi:10.1016/s0167-4781(00)00153-6. PMID 10978529.
  


• 
  Szekely AM, Chen YH, Zhang C, et al. (2000). "Werner protein recruits DNA polymerase δ to the nucleolus". Proc. Natl. Acad. Sci. U.S.A. 97 (21): 11365–70. Bibcode:2000PNAS...9711365S. doi:10.1073/pnas.97.21.11365. PMC 17206. PMID 11027336.
  


• 
  He H, Tan CK, Downey KM, So AG (2001). "A tumor necrosis factor α- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase δ and proliferating cell nuclear antigen". Proc. Natl. Acad. Sci. U.S.A. 98 (21): 11979–84. Bibcode:2001PNAS...9811979H. doi:10.1073/pnas.221452098. PMC 59753. PMID 11593007.
  


• 
  Lu X, Tan CK, Zhou JQ, et al. (2002). "Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta". J. Biol. Chem. 277 (27): 24340–5. doi:10.1074/jbc.M200065200. PMID 11986310.
  


• 
  Ohta S, Shiomi Y, Sugimoto K, et al. (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
  


• 
  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  


• 
  Liu L, Rodriguez-Belmonte EM, Mazloum N, et al. (2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". J. Biol. Chem. 278 (12): 10041–7. doi:10.1074/jbc.M208694200. PMID 12522211.
  


• 
  Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  


• 
  Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  


• 
  Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  


• 
  Tsurimoto T, Shinozaki A, Yano M, et al. (2005). "Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta". Genes Cells. 10 (1): 13–22. doi:10.1111/j.1365-2443.2004.00812.x. PMID 15670210.
  


• 
  Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
  

v t e DNA replication (comparing Prokaryotic to Eukaryotic)
Initiation	Prokaryotic (initiation) Pre-replication complex dnaC Cdc6 Helicase dnaA dnaB T7 Primase dnaG Eukaryotic (preparation in G1 phase) Pre-replication complex Origin recognition complex ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 Cdc6 Cdt1 Minichromosome maintenance MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 Licensing factor Autonomously replicating sequence Single-strand binding protein SSBP2 SSBP3 SSBP4 RNase H RNASEH1 RNASEH2A Helicase: HFM1 Primase: PRIM1 PRIM2 Both Origin of replication/Ori/Replicon Replication fork Lagging and leading strands Okazaki fragments Primer
Replication	Prokaryotic (elongation) DNA polymerase III holoenzyme dnaC dnaE dnaH dnaN dnaQ dnaT dnaX holA holB holC holD holE Replisome DNA ligase DNA clamp Topoisomerase DNA gyrase Prokaryotic DNA polymerase: DNA polymerase I Klenow fragment Eukaryotic (synthesis in S phase) Replication factor C RFC1 Flap endonuclease FEN1 Topoisomerase Replication protein A RPA1 Eukaryotic DNA polymerase: alpha POLA1 POLA2 PRIM1 PRIM2 delta POLD1 POLD2 POLD3 POLD4 epsilon POLE POLE2 POLE3 POLE4 DNA clamp PCNA Control of chromosome duplication Both Movement: Processivity DNA ligase
Termination	Telomere: Telomerase TERT TERC DKC1

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it. v t e

This page is only for reference, If you need detailed information, please check here