Chronotherapy (treatment scheduling)

"Chronotherapy" redirects here. For other uses, see Chronotherapy (sleep phase).

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Chronotherapy (treatment scheduling)
MeSH	D019454
[edit on Wikidata]

Chronotherapy, also called chronotherapeutics^[1] or chronotherapeutic drug delivery,^[2] refers to the use of circadian or other rhythmic cycles of a condition's symptoms and/or of the individual being treated in the application of therapy.^[2] Examples of this are treatments of psychiatric and somatic diseases that are administered according to a schedule that corresponds to these rhythms in order to maximize effectiveness and minimize side effects of the therapy.^[3]

Chronotherapy is used in various clinical fields such as the treatments of asthma,^{[4][5][non-primary source needed]}hypertension,^[6] and bipolar disorder^[7][8].

In the treatment of psychiatric conditions including bipolar depression^[9][10], a form of chronotherapy combining intermittent sleep deprivation and morning bright light has shown efficacy and relative tolerability in a number of controlled studies.^[11][12][13]

See also

• Personalized medicine

References

1. 
   ^ "Medical dictionary". Merriam-Webster. Retrieved 6 January 2017..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output .citation q{quotes:"""""""'""'"}.mw-parser-output .citation .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-maint{display:none;color:#33aa33;margin-left:0.3em}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}
   


2. 
   ^ ^ab Sajan J (October 2009). "Chronotherapeutics and Chronotherapeutic Drug Delivery Systems". Tropical Journal of Pharmaceutical Research. 8 (5): 467–475. doi:10.4314/tjpr.v8i5.48091. ISSN 1596-5996. Retrieved 6 January 2017. ...drug availability is timed to match rhythms of disease in order to optimize therapeutic outcomes and minimize side effects.
   


3. 
   ^ "Dictionary Definition".
   


4. 
   ^ Pincus DJ, Szefler SJ, Ackerson LM, Martin RJ (June 1995). "Chronotherapy of asthma with inhaled steroids: the effect of dosage timing on drug efficacy". The Journal of Allergy and Clinical Immunology. 95 (6): 1172–8. doi:10.1016/S0091-6749(95)70073-0. PMID 7797785.
   


5. 
   ^ Pincus DJ, Humeston TR, Martin RJ (December 1997). "Further studies on the chronotherapy of asthma with inhaled steroids: the effect of dosage timing on drug efficacy". The Journal of Allergy and Clinical Immunology. 100 (6 Pt 1): 771–4. doi:10.1016/S0091-6749(97)70272-0. PMID 9438485.
   


6. 
   ^ Hermida RC, Ayala DE, Portaluppi F (August 2007). "Circadian variation of blood pressure: the basis for the chronotherapy of hypertension". Advanced Drug Delivery Reviews. 59 (9–10): 904–22. doi:10.1016/j.addr.2006.08.003. PMID 17659807.
   


7. 
   ^ Benedetti F, Barbini B, Fulgosi MC, Colombo C, Dallaspezia S, Pontiggia A, Smeraldi E (December 2005). "Combined total sleep deprivation and light therapy in the treatment of drug-resistant bipolar depression: acute response and long-term remission rates". The Journal of Clinical Psychiatry. 66 (12): 1535–40. PMID 16401154.
   


8. 
   ^ Benedetti F, Riccaboni R, Locatelli C, Poletti S, Dallaspezia S, Colombo C (February 2014). "Rapid treatment response of suicidal symptoms to lithium, sleep deprivation, and light therapy (chronotherapeutics) in drug-resistant bipolar depression". The Journal of Clinical Psychiatry. 75 (2): 133–40. doi:10.4088/JCP.13m08455. PMID 24345382.
   


9. 
   ^ Benedetti F, Barbini B, Fulgosi MC, Colombo C, Dallaspezia S, Pontiggia A, Smeraldi E (December 2005). "Combined total sleep deprivation and light therapy in the treatment of drug-resistant bipolar depression: acute response and long-term remission rates". The Journal of Clinical Psychiatry. 66 (12): 1535–40. PMID 16401154.
   


10. 
    ^ Benedetti F, Riccaboni R, Locatelli C, Poletti S, Dallaspezia S, Colombo C (February 2014). "Rapid treatment response of suicidal symptoms to lithium, sleep deprivation, and light therapy (chronotherapeutics) in drug-resistant bipolar depression". The Journal of Clinical Psychiatry. 75 (2): 133–40. doi:10.4088/JCP.13m08455. PMID 24345382.
    


11. 
    ^ Benedetti F, Barbini B, Colombo C, Smeraldi E (December 2007). "Chronotherapeutics in a psychiatric ward". Sleep Medicine Reviews. 11 (6): 509–22. doi:10.1016/j.smrv.2007.06.004. PMID 17689120.
    


12. 
    ^ Benedetti F (December 2012). "Antidepressant chronotherapeutics for bipolar depression". Dialogues in Clinical Neuroscience. 14 (4): 401–11. PMC 3553570. PMID 23393416.
    


13. 
    ^ Dallaspezia S, Suzuki M, Benedetti F (December 2015). "Chronobiological Therapy for Mood Disorders". Current Psychiatry Reports. 17 (12): 95. doi:10.1007/s11920-015-0633-6. PMID 26478195.
    

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